四氯化碳致大鼠肝纤维化模型血液流变学性质的研究

张万国; 胡晋红; 蔡溱

四氯化碳致大鼠肝纤维化模型血液流变学性质的研究

投稿时间：2000-09-03 点此下载全文

引用本文：张万国,胡晋红,蔡溱.四氯化碳致大鼠肝纤维化模型血液流变学性质的研究[J].药学实践杂志,2001,(2):78~79

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作者	单位
张万国	第二军医大学长海医院药学部, 上海 200433
胡晋红	第二军医大学长海医院药学部, 上海 200433
蔡溱	第二军医大学长海医院药学部, 上海 200433

中文摘要:目的研究大鼠肝纤维化时血液流变学性质的变化特征。方法以四氯化碳诱导大鼠肝纤维化模型,检测血液粘度、血浆粘度、红细胞压积、红细胞特性指数等血液流变学参数,分析其变化特征。结果与正常组比较,模型组大鼠全血粘度、全血还原粘度、血浆粘度、红细胞压积、红细胞聚集指数及红细胞刚性指数明显增高。结论大鼠肝纤维化时血液粘度增大,红细胞流变性能减弱,易引发微循环障碍,加重肝纤维化的发展。

中文关键词:肝纤维化血液流变学红细胞四氯化碳

Study on hemorheological changes of carbon tetrachloride(CCl₄)induced hepatic fibrosis in rat

Abstract:OBJECTIVE To study the hemorheological paramenters in rat with hepatic fibrosis. METHODS Hepatic fibrosis in rat was induced by CCl_{4 treatment. Whole blood viscosity, plasma viscosity, Hematocrit(H_ct) and dynamic parameters of red blood cell(RBC) were investigated. RESULTS As compared with the normal group, the hemorheological parameters such as whole blood viscosity, plasma viscosity, Hematocrit(H_ct), RBC's aggregation and rigidity were increased obviously. CONCLUSION High blood vicosity and low RBC's deformation ability can lead to blood circulation obstacle, thus will aggravate hepatic fibrosis.}

keywords:hepatic fibosis hemorheology red blood cell carbon tetrachloride

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