| 金丝桃细胞毒作用和抗肿瘤作用研究 |
| 投稿时间：2000-06-27 点此下载全文 |
| 引用本文：项光亚,杨瑜,阮金兰,周宜开.金丝桃细胞毒作用和抗肿瘤作用研究[J].药学实践杂志,2001,(1):16~18,64 |
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| 中文摘要:目的 研究金丝桃体外细胞毒作用和体内抗肿瘤作用。方法 MTT和SRB体外实验法和皮下注射给药体内抗肿瘤法。结果 体外细胞毒研究表明,提取物F003、F004、F006以及化合物金丝桃内酯丙、槲皮素、槲皮苷对不同的癌细胞具有细胞毒作用;体内皮下注射 20mg/(kg·d)×10d剂量的F003、F004、F005对小鼠S180肉瘤的抑制率分别为 20.7%、12.4 %、31.4 %。结论 金丝桃在体外实验显示一定的细胞毒作用,体内实验有抗肿瘤作用,具有进一步研究开发的价值。 |
| 中文关键词:金丝桃 细胞毒作用 抗肿瘤作用 |
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| Studies of cytotoxic effect and antitumor effect by Hypericum chinense |
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| Abstract:OBJECTIVE To study the cytotoxic effect in vitro and antitumor effect in vivo of Hypericum chinense.METHODS MTT and SRB assay method in vitro and antitumor test in vivo were used.RESULTS The extracts F003、F004、F006 and the compounds hyperlacton C, quercetin, quercitrin show cytotoxic effect on different carcinoma cell in vitro; Under the dose of 20.0mg/(kg·d) × 10d, the inhibitory rates of F003、F004、F005 on S180 in mice were 20.7%、12.4%、31.4 %.CONCLUSION Hypericum chinense show cytotoxic effect in vitro and antitumor effect in viva and should he studied further. |
| keywords:Hypericum chinense cytotoxic effect antitumor effect |
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