| 辐射法制备喃氟啶植入剂的家兔药物动力学 |
| 投稿时间：1999-06-25 点此下载全文 |
| 引用本文：王文俭,蒋雪涛,郭涛,董志超.辐射法制备喃氟啶植入剂的家兔药物动力学[J].药学实践杂志,2000,(1):19~21 |
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| 中文摘要:目的 用辐射法制备喃氟啶植入剂,并对其体外溶出和家兔体内药物动力学进行研究。方法 用辐射法制备以聚甲基丙烯酸羟乙酯[Poly(2-hydroxyelthyl methacrylate),p(HEMA)]和胶原蛋白(Collagen)复合物[以下简称p-(HEMA)-胶原]为基质的喃氟啶缓释植入剂,并做体外溶出和家兔体内药物动力学研究,用注射剂作为对照。结果 植入剂的体外释药过程符合Higuchi动力学,体外溶出指数为t1/2=99h,t0.9=32.7h,家兔体内药动学参数为：AUC=268.666h·μg/ml,MRT=41.704h,ka=0.334/h.结论 用辐射法制备的p-(HEMA)-胶原可以作为抗癌药物的植入缓释载体进一步探索研究。 |
| 中文关键词:喃氟啶 辐射 植入剂 胶原蛋白 聚甲基丙烯酸羟乙酯-胶原蛋白复合物 |
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| The pharmacokinetics in rabbits of the fluorofur implants made by irradiation-induced polymerization |
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| Abstract:OBJECTIVE To investigate the in vitro release and the pharmacokinetics in rabbits of the fluorofur implants.METHODS The implant,poly(2-hydroxyelthyl methacrylate)[poly(HEMA)]-collagen composite,made by fluorofur injection. RESULTS The release profiles in vitro conformed to Higuchi kinetics. The release index of the implant was t1/2=9.9h, t0.9=32.7h. The pharmacokinetic parameters in rabbits were:AUC=268.666h·μg/ml,MRT=41.704h,ka=0.334/h. CONCLUSION: The results clearly indicated that the poly(HEMA)-collagen hydrogel made by irradiation-induced polymerization offers excellent potential as a carrier for the sustained release implant of anticancer drugs. |
| keywords:fluorofur implant irradiation collagen poly(HEMA)-collagen composite |
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