| 氟罗沙星针剂原料的合成工艺 |
| 投稿时间：1999-02-09 点此下载全文 |
| 引用本文：鄢立刚,孙华,宋聚忠,谢怀江.氟罗沙星针剂原料的合成工艺[J].药学实践杂志,1999,(6):349~351 |
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| 中文摘要:目的 对注射用氟罗沙星原料的合成工艺进行探讨研究。方法 以6,7,8-三氟-1,4-二氢-4-氧喹啉-3-羧酸乙酯为原料,经4 步反应得到氟罗沙星。结果 本品的元素分析、红外、质谱、核磁共振图谱数据与文献报道一致,总收率为56.3%,产品经质量测定,完全符合注射用原料的标准。结论 采用该路线工艺生产的氟罗沙星原料产品符合注射用原料的标准,可直接用于注射剂的生产。 |
| 中文关键词:氟罗沙星 喹诺酮 合成工艺 |
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| Synthesis technology of fleroxacin material for injection |
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| Abstract:OBJECTIVE To study the synthetic method and technology of fleroxacin material for injection. METHODS This compound was synthesized using 6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-ethylcarbonate as material. RESULTS The element analysis,IR,MS and HNMR of synthetic product were comformable to literature,the total yield was 56.3%.The product was identified,its quality accords with injection′s demands. CONCLUSION Fleroxacin material of this technology synthesized accords with injection′s demands,and it can be used for injection′s production. |
| keywords:fleroxacin quinolone synthesis technology |
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