| 污染性切口预防性抗生素应用的临床意义 |
| 投稿时间：1999-02-26 点此下载全文 |
| 引用本文：郑正葆,杨幼萍.污染性切口预防性抗生素应用的临床意义[J].药学实践杂志,1999,(3):131~133 |
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| 中文摘要:目的 术前预防性应用抗生素,以观察感染性并发症的预防效果。方法 按Altemyer标准Ⅱ——Ⅳ类手术,1996年5月～1998年4月术前预防性应用抗生素100例,并与对照组100例进行分析。预防组分别于术前2h使用丁胺卡那霉素0.4g加0.5%甲硝唑100ml静脉滴注33例；头孢唑啉4.0g加0.5%甲硝唑100ml静脉滴注32例；头孢他啶1.0g静脉推注加0.5%甲硝唑100ml静脉滴注45例。手术超过4h者术中重复给予1个剂量的抗生素。然后观察术后感染的并发症,并以切口感染为重点对两组进行比较分析。结果 预防组切口感染3例,2例为丁胺卡那霉素加0.5%甲硝唑,1例为头孢唑啉加0.5%甲硝唑。对照组切口感染9例,细菌培养大肠杆菌2例,金黄色葡萄球菌1例。结论 应用抗生素对预防术后感染性并发症的发生,尤其是切口感染有一定效果,其中头孢他啶效果肯定。 |
| 中文关键词:污染性切口 预防性应用抗生素 术后感染 |
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| The clinical significance of preventive use of antibiotics in polluted wound |
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| Abstract:OBJECTIVE The preventive use of antibiotics before operation and examine the effect of preventing infective complications. METHODS Operations of standard Altemye were applied.Before the operation preventive administration of antibiotics was used for one group of 100 patients during May 1996 and April 1998.At the same time,the antibiotics is not used in another group of the 100similar patients who were compared.The following was used in the preventive administration group:amikacin sulfate of 0.4g plus 0.5% metronidazole of 100ml through I.V.gtt in 33 of 100;cefazoline of 4g plus 0.5% metronidazole of 100ml through I.V.gtt in 32 of 100;cefatazidine of 1g though I.V.plus 0.5% metronidazole of 100ml through I.V.gtt in 45 of 100.For those whose operation was over 4 hours,antibiotics of one dose was reused during the operation.Then infected complications after the operation were observed and the 2 groups were compared in the infection of wound. RESULTS 3 patients of the preventive administration group were infected,Amikacin Sulfate&Metronidazole was used in 2 of 3 and Cefazoline&Metronidazole were used in 1 of 3.Compared to the control group ,9 patients got infected in the wound,2of which were done by Escherichia,another one of which by S.aureus. CONCLUSION Operation for polluted wound in which preventive adminisrtation of antibioties was used have given effect on preventing the complication caused by infection after operation especially the infection of wound.From chosen antibiotics,Cefatazidine would be more effective. |
| keywords:pollutde wound preventive adminisrtation antibiotics infection afteropration |
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